Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea
المؤلفون المشاركون
Li, Kun
Chen, Zhiting
Qin, Yanwen
Wei, Yong-Xiang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Obstructive sleep apnea (OSA) is a common disease.
It can cause many serious complications.
OSA may increase the risk of hypertension.
However, the exact mechanism of OSA causing hypertension is not fully understood.
YKL-40/chitinase-3-like protein-1 plays an important role in vascular injury, repair, and generation.
We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients.
Methods.
All subjects were examined by polysomnography (PSG) and the expression of YKL-40 in the plasm of the subjects was measured by luminex.
Carotid intima-media thickness (CIMT) was measured by B-mode ultrasound.
Results.
According to the conditions of OSA and hypertension, we studied four groups of 157 subjects, including OSA group (OSA, N=77), OSA with hypertension group (OSA+HT, N=37), hypertension group (HT, N=20), and healthly group (Con, N=23).
YKL-40 levels were significantly elevated in OSA, OSA+HT, and HT group compared to Con groups.
We used the ROC to predict the sensitivity and specificity of YKL-40 in all OSA patients or all hyperpietic patients.
For OSA patients, the AUC of YKL-40 is 0.807 (95% confidence interval 0.725–0.888; p<0.01).
For hyperpietic patients, the AUC of YKL-40 is 0.656 (95% confidence interval 0.570–0.742, p=0.01).
There was a significant correlation between the parameter of OSA and hypertension and YKL-40 (P<0.05) and a significant correlation between Max-CIMT and YKL-40 (P<0.05).
Conclusion.
Elevated circulating levels of YKL-40 are associated with hypertension in OSA patients.
The specificity of YKL-40 suggests that it could be a potential biomarker for OSA and hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Kun& Chen, Zhiting& Qin, Yanwen& Wei, Yong-Xiang. 2019. Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Kun…[et al.]. Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Kun& Chen, Zhiting& Qin, Yanwen& Wei, Yong-Xiang. Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر