Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea
Joint Authors
Li, Kun
Chen, Zhiting
Qin, Yanwen
Wei, Yong-Xiang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Obstructive sleep apnea (OSA) is a common disease.
It can cause many serious complications.
OSA may increase the risk of hypertension.
However, the exact mechanism of OSA causing hypertension is not fully understood.
YKL-40/chitinase-3-like protein-1 plays an important role in vascular injury, repair, and generation.
We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients.
Methods.
All subjects were examined by polysomnography (PSG) and the expression of YKL-40 in the plasm of the subjects was measured by luminex.
Carotid intima-media thickness (CIMT) was measured by B-mode ultrasound.
Results.
According to the conditions of OSA and hypertension, we studied four groups of 157 subjects, including OSA group (OSA, N=77), OSA with hypertension group (OSA+HT, N=37), hypertension group (HT, N=20), and healthly group (Con, N=23).
YKL-40 levels were significantly elevated in OSA, OSA+HT, and HT group compared to Con groups.
We used the ROC to predict the sensitivity and specificity of YKL-40 in all OSA patients or all hyperpietic patients.
For OSA patients, the AUC of YKL-40 is 0.807 (95% confidence interval 0.725–0.888; p<0.01).
For hyperpietic patients, the AUC of YKL-40 is 0.656 (95% confidence interval 0.570–0.742, p=0.01).
There was a significant correlation between the parameter of OSA and hypertension and YKL-40 (P<0.05) and a significant correlation between Max-CIMT and YKL-40 (P<0.05).
Conclusion.
Elevated circulating levels of YKL-40 are associated with hypertension in OSA patients.
The specificity of YKL-40 suggests that it could be a potential biomarker for OSA and hypertension.
American Psychological Association (APA)
Li, Kun& Chen, Zhiting& Qin, Yanwen& Wei, Yong-Xiang. 2019. Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125875
Modern Language Association (MLA)
Li, Kun…[et al.]. Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1125875
American Medical Association (AMA)
Li, Kun& Chen, Zhiting& Qin, Yanwen& Wei, Yong-Xiang. Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1125875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125875