![](/images/graphics-bg.png)
Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against IschemiaReperfusion Injury in Mice
المؤلفون المشاركون
Shao, Jun
Miao, Chen
Geng, Zhi
Gu, Maohong
Wu, Yanhu
Li, Qingguo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Autophagy is involved in the development of numerous illnesses, including ischemia/reperfusion (I/R).
Endothelial nitric oxide synthase (eNOS) participates in the protective effects of ischemic postconditioning (IPostC).
However, it remains unclear whether eNOS-mediated autophagy serves as a critical role in IPostC in the hearts of mice, in protecting against I/R injury.
In the present study, the hearts of mice with left anterior descending coronary artery ligation were studied as I/R models.
H9c2 cells underwent exposure to hypoxia/reoxygenation (H/R) and were examined as in vitro model.
IPostC reduced mice myocardial infarct size and improved the structure of the heart.
IPostC increased the formation of autophagosomes and increased the phosphorylation of eNOS and adenosine monophosphate-activated protein kinase (AMPK).
Autophagy and eNOS inhibition suppressed the cardioprotective effects of IPostC.
AMPK or eNOS inhibition abolished the improvement effect of IPostC on autophagy.
AMPK inhibition decreased eNOS phosphorylation in the heart.
Additionally, H9c2 cells suffering hypoxia were used as in vitro model.
Autophagy or eNOS inhibition abolished the protective effects of hypoxic postconditioning (HPostC) against H/R injury.
AMPK and eNOS inhibition/knockout decreased autophagic activity in the HPostC group.
These results indicated that IPostC protects the heart against I/R injury, partially via promoting AMPK/eNOS-mediated autophagy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shao, Jun& Miao, Chen& Geng, Zhi& Gu, Maohong& Wu, Yanhu& Li, Qingguo. 2019. Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against IschemiaReperfusion Injury in Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125888
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shao, Jun…[et al.]. Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against IschemiaReperfusion Injury in Mice. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1125888
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shao, Jun& Miao, Chen& Geng, Zhi& Gu, Maohong& Wu, Yanhu& Li, Qingguo. Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against IschemiaReperfusion Injury in Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125888
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125888
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)