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C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats
المؤلفون المشاركون
Dergilev, K.
Tsokolaeva, Z.
Makarevich, P.
Zubkova, E.
Boldyreva, M.
Ratner, E.
Dyikanov, D.
Menshikov, M.
Ovchinnikov, A.
Ageev, F.
Parfyonova, Ye.
Beloglazova, I. B.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The adult heart contains small populations of multipotent cardiac progenitor cells (CPC) that present a convenient and efficient resource for treatment of myocardial infarction.
Several clinical studies of direct CPC delivery by injection have already been performed but showed low engraftment rate that limited beneficial effects of procedure.
«Cell sheet» technology has been developed to facilitate longer retention of grafted cells and show new directions for cell-based therapy using this strategy.
In this study we hypothesized that СPC-based cell sheet transplantation could improve regeneration after myocardial infarction.
We demonstrated that c-kit+ CPC were able to form cell sheets on temperature-responsive surfaces.
Cell sheet represented a well-organized structure, in which CPC survived, retained ability to proliferate, expressed progenitor cell marker Gata-4 formed connexin-43+ gap junctions, and were surrounded by significant amount of extracellular matrix proteins.
Transplantation of cell sheets after myocardial infarction resulted in CPC engraftment as well as their proliferation, migration, and differentiation; cell sheets also stimulated neovascularization and cardiomyocyte proliferation in underlining myocardium and ameliorated left ventricular remodeling.
Obtained data strongly supported potential use of CPC sheet transplantation for repair of damaged heart.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dergilev, K.& Tsokolaeva, Z.& Makarevich, P.& Beloglazova, I. B.& Zubkova, E.& Boldyreva, M.…[et al.]. 2018. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1125897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dergilev, K.…[et al.]. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1125897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dergilev, K.& Tsokolaeva, Z.& Makarevich, P.& Beloglazova, I. B.& Zubkova, E.& Boldyreva, M.…[et al.]. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1125897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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