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C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats
Joint Authors
Dergilev, K.
Tsokolaeva, Z.
Makarevich, P.
Zubkova, E.
Boldyreva, M.
Ratner, E.
Dyikanov, D.
Menshikov, M.
Ovchinnikov, A.
Ageev, F.
Parfyonova, Ye.
Beloglazova, I. B.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The adult heart contains small populations of multipotent cardiac progenitor cells (CPC) that present a convenient and efficient resource for treatment of myocardial infarction.
Several clinical studies of direct CPC delivery by injection have already been performed but showed low engraftment rate that limited beneficial effects of procedure.
«Cell sheet» technology has been developed to facilitate longer retention of grafted cells and show new directions for cell-based therapy using this strategy.
In this study we hypothesized that СPC-based cell sheet transplantation could improve regeneration after myocardial infarction.
We demonstrated that c-kit+ CPC were able to form cell sheets on temperature-responsive surfaces.
Cell sheet represented a well-organized structure, in which CPC survived, retained ability to proliferate, expressed progenitor cell marker Gata-4 formed connexin-43+ gap junctions, and were surrounded by significant amount of extracellular matrix proteins.
Transplantation of cell sheets after myocardial infarction resulted in CPC engraftment as well as their proliferation, migration, and differentiation; cell sheets also stimulated neovascularization and cardiomyocyte proliferation in underlining myocardium and ameliorated left ventricular remodeling.
Obtained data strongly supported potential use of CPC sheet transplantation for repair of damaged heart.
American Psychological Association (APA)
Dergilev, K.& Tsokolaeva, Z.& Makarevich, P.& Beloglazova, I. B.& Zubkova, E.& Boldyreva, M.…[et al.]. 2018. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1125897
Modern Language Association (MLA)
Dergilev, K.…[et al.]. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1125897
American Medical Association (AMA)
Dergilev, K.& Tsokolaeva, Z.& Makarevich, P.& Beloglazova, I. B.& Zubkova, E.& Boldyreva, M.…[et al.]. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1125897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125897