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Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
المؤلفون المشاركون
Li, Yan
Yu, Haiyang
Han, Fengfeng
Wang, Mengmeng
Luo, Yong
Guo, Xuejun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Lung cancer is among the most common malignancies with a poor 5-year survival rate reaching only 16%.
Thus, new effective treatment modalities and drugs are urgently needed for the treatment of this malignancy.
In this study, we conducted the first investigation of the effects of Biochanin A on lung cancer and revealed the mechanisms underlying its potential anticancer effects.
Biochanin A decreased cell viability in a time-dependent and dose-dependent manner and suppressed colony formation in A549 and 95D cells.
In addition, Biochanin A induced S phase arrest and apoptosis and decreased mitochondrial membrane potential (ΔΨm) in A549 and 95D cells in a dose-dependent manner.
Our results of subcutaneous xenograft models showed that the growth of Biochanin A group was significantly inhibited compared with that of control groups.
Finally, P21, Caspase-3, and Bcl-2 were activated in Biochanin A-treated cells and Biochanin A-treated xenografts which also demonstrated that Biochanin A induced cell cycle arrest and apoptosis in lung cancer cells by regulating expression of cell cycle-related proteins and apoptosis-related proteins.
In conclusion, this study suggests that Biochanin A inhibits the proliferation of lung cancer cells and induces cell cycle arrest and apoptosis mainly by regulating cell cycle-related protein expression and activating the Bcl-2 and Caspase-3 pathways, thus suggesting that Biochanin A may be a promising drug to treat lung cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yan& Yu, Haiyang& Han, Fengfeng& Wang, Mengmeng& Luo, Yong& Guo, Xuejun. 2018. Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1125903
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yan…[et al.]. Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1125903
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yan& Yu, Haiyang& Han, Fengfeng& Wang, Mengmeng& Luo, Yong& Guo, Xuejun. Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1125903
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125903
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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