Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
Joint Authors
Li, Yan
Yu, Haiyang
Han, Fengfeng
Wang, Mengmeng
Luo, Yong
Guo, Xuejun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Lung cancer is among the most common malignancies with a poor 5-year survival rate reaching only 16%.
Thus, new effective treatment modalities and drugs are urgently needed for the treatment of this malignancy.
In this study, we conducted the first investigation of the effects of Biochanin A on lung cancer and revealed the mechanisms underlying its potential anticancer effects.
Biochanin A decreased cell viability in a time-dependent and dose-dependent manner and suppressed colony formation in A549 and 95D cells.
In addition, Biochanin A induced S phase arrest and apoptosis and decreased mitochondrial membrane potential (ΔΨm) in A549 and 95D cells in a dose-dependent manner.
Our results of subcutaneous xenograft models showed that the growth of Biochanin A group was significantly inhibited compared with that of control groups.
Finally, P21, Caspase-3, and Bcl-2 were activated in Biochanin A-treated cells and Biochanin A-treated xenografts which also demonstrated that Biochanin A induced cell cycle arrest and apoptosis in lung cancer cells by regulating expression of cell cycle-related proteins and apoptosis-related proteins.
In conclusion, this study suggests that Biochanin A inhibits the proliferation of lung cancer cells and induces cell cycle arrest and apoptosis mainly by regulating cell cycle-related protein expression and activating the Bcl-2 and Caspase-3 pathways, thus suggesting that Biochanin A may be a promising drug to treat lung cancer.
American Psychological Association (APA)
Li, Yan& Yu, Haiyang& Han, Fengfeng& Wang, Mengmeng& Luo, Yong& Guo, Xuejun. 2018. Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1125903
Modern Language Association (MLA)
Li, Yan…[et al.]. Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1125903
American Medical Association (AMA)
Li, Yan& Yu, Haiyang& Han, Fengfeng& Wang, Mengmeng& Luo, Yong& Guo, Xuejun. Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1125903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125903