Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring

المؤلفون المشاركون

Rudà, Roberta
Chiavazza, C.
Pellerino, A.
Ferrio, F.
Soffietti, R.
Cistaro, Angelina

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-06-21

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الطب البشري

الملخص EN

Primary Central Nervous System Lymphoma (PCNSL) is a rare neoplasm that can involve brain, eye, leptomeninges, and rarely spinal cord.

PCNSL lesions most typically enhance homogeneously on T1-weighted magnetic resonance imaging (MRI) and appear T2-hypointense, but high variability in MRI features is commonly encountered.

Neurological symptoms and MRI findings may mimic high grade gliomas (HGGs), tumefactive demyelinating lesions (TDLs), or infectious and granulomatous diseases.

Advanced MRI techniques (MR diffusion, spectroscopy, and perfusion) and metabolic imaging, such as Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) or amino acid PET (usually employing methionine), may be useful in distinguishing these different entities and monitoring the disease course.

Moreover, emerging data suggest a role for cerebrospinal fluid (CSF) markers in predicting prognosis and response to treatments.

In this review, we will address the challenges in PCNSL diagnosis, assessment of response to treatments, and evaluation of potential neurotoxicity related to chemotherapy and radiotherapy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chiavazza, C.& Pellerino, A.& Ferrio, F.& Cistaro, Angelina& Soffietti, R.& Rudà, Roberta. 2018. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1125947

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chiavazza, C.…[et al.]. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1125947

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chiavazza, C.& Pellerino, A.& Ferrio, F.& Cistaro, Angelina& Soffietti, R.& Rudà, Roberta. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1125947

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1125947