Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring
Joint Authors
Rudà, Roberta
Chiavazza, C.
Pellerino, A.
Ferrio, F.
Soffietti, R.
Cistaro, Angelina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Primary Central Nervous System Lymphoma (PCNSL) is a rare neoplasm that can involve brain, eye, leptomeninges, and rarely spinal cord.
PCNSL lesions most typically enhance homogeneously on T1-weighted magnetic resonance imaging (MRI) and appear T2-hypointense, but high variability in MRI features is commonly encountered.
Neurological symptoms and MRI findings may mimic high grade gliomas (HGGs), tumefactive demyelinating lesions (TDLs), or infectious and granulomatous diseases.
Advanced MRI techniques (MR diffusion, spectroscopy, and perfusion) and metabolic imaging, such as Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) or amino acid PET (usually employing methionine), may be useful in distinguishing these different entities and monitoring the disease course.
Moreover, emerging data suggest a role for cerebrospinal fluid (CSF) markers in predicting prognosis and response to treatments.
In this review, we will address the challenges in PCNSL diagnosis, assessment of response to treatments, and evaluation of potential neurotoxicity related to chemotherapy and radiotherapy.
American Psychological Association (APA)
Chiavazza, C.& Pellerino, A.& Ferrio, F.& Cistaro, Angelina& Soffietti, R.& Rudà, Roberta. 2018. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1125947
Modern Language Association (MLA)
Chiavazza, C.…[et al.]. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1125947
American Medical Association (AMA)
Chiavazza, C.& Pellerino, A.& Ferrio, F.& Cistaro, Angelina& Soffietti, R.& Rudà, Roberta. Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1125947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125947