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Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation
المؤلفون المشاركون
Jung, Kyungsook
Jang, Hyun-Jae
Lee, Seung-Jae
Lim, Hyung-Jin
Lee, Soyoung
Park, Chan Sun
Lee, Seung Woong
Rho, Mun-Chual
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Ampelopsis brevipedunculata (Maxim.) Trautv.
(AB), a traditional East Asian medicine, exhibits protective effects against several inflammatory diseases.
Our search for an inhibitor of IL-6-induced JAK2/STAT3 activation revealed that AB ethanolic extract (ABE) had a significant inhibitory effect on IL-6-induced STAT3 expression in Hep3B cells.
The isolation and purification of an EtOAc-soluble fraction of ABE (ABEA) using reversed-phase high-performance liquid chromatography (RP-HPLC) afforded 17 compounds.
The structures of these compounds (1-17) were elucidated based on 1H and 13C nuclear magnetic resonance (NMR) spectroscopy as well as electrospray-ionization mass spectrometry (ESI-MS) data.
ABE and ABEA were screened by a luciferase assay using Hep3B cells transfected with the STAT3 reporter gene.
ABEA exhibited potent inhibitory effects on IL-6-induced STAT3 expression; moreover, these effects arose from the inhibition of the phosphorylation of the STAT3, JAK2, and ERK proteins in U266 cells.
In addition, the compounds isolated from ABEA were measured for their inhibitory effects on IL-6-stimulated STAT3 expression.
Of the compounds isolated, betulin showed the greatest inhibitory effects on IL-6-induced STAT3 activation in the luciferase assay (IC50 value: 3.12 μM).
Because of its potential for inhibiting STAT3 activation, A.
brevipedunculata could be considered a source of compounds of pharmaceutical interest.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Hyun-Jae& Lee, Seung-Jae& Lim, Hyung-Jin& Jung, Kyungsook& Lee, Soyoung& Park, Chan Sun…[et al.]. 2018. Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Hyun-Jae…[et al.]. Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Hyun-Jae& Lee, Seung-Jae& Lim, Hyung-Jin& Jung, Kyungsook& Lee, Soyoung& Park, Chan Sun…[et al.]. Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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