Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate
المؤلفون المشاركون
Kenechukwu, Franklin Chimaobi
Attama, Anthony Amaechi
Ibezim, Emmanuel Chinedum
Nnamani, Petra Obioma
Umeyor, Chukwuebuka Emmanuel
Uronnachi, Emmanuel Maduabuchi
Momoh, Mumuni Audu
Akpa, Paul Achile
Ozioko, Angela Chizoba
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-06
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvovaginal candidiasis (VVC).
Lipid matrices (LMs) consisting of rational blends of SF and SO with or without PEG-4000 were prepared by fusion and characterized and employed to formulate MN-loaded solid lipid microparticles (SLMs) by melt-homogenization.
The SLMs were characterized for physicochemical properties, anticandidal activity, and stability.
Spherical discrete microparticles with good physicochemical properties and mean diameters suitable for vaginal drug delivery were obtained.
Formulations based on SO:SF (1:9) and containing highest concentrations of PEG-4000 (4 %w/w) and MN (3.0 %w/w) were stable and gave highest encapsulation efficiency (83.05–87.75%) and inhibition zone diameter (25.87±0.94–26.33±0.94 mm) and significantly (p<0.05) faster and more powerful fungicidal activity regarding killing rate constant values (7.10 x 10−3–1.09 x 10−2 min−1) than commercial topical solution of MN (Fungusol®) (8.00 x 10−3 min−1) and pure MN sample (5.160 x 10−3 min−1).
This study has shown that MN-loaded SLMs based on molecularly PEGylated lipid matrices could provide a better option to deal with VVC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kenechukwu, Franklin Chimaobi& Attama, Anthony Amaechi& Ibezim, Emmanuel Chinedum& Nnamani, Petra Obioma& Umeyor, Chukwuebuka Emmanuel& Uronnachi, Emmanuel Maduabuchi…[et al.]. 2018. Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate. BioMed Research International،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1126035
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kenechukwu, Franklin Chimaobi…[et al.]. Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate. BioMed Research International No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1126035
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kenechukwu, Franklin Chimaobi& Attama, Anthony Amaechi& Ibezim, Emmanuel Chinedum& Nnamani, Petra Obioma& Umeyor, Chukwuebuka Emmanuel& Uronnachi, Emmanuel Maduabuchi…[et al.]. Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1126035
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126035
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر