Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Joint Authors

Kenechukwu, Franklin Chimaobi
Attama, Anthony Amaechi
Ibezim, Emmanuel Chinedum
Nnamani, Petra Obioma
Umeyor, Chukwuebuka Emmanuel
Uronnachi, Emmanuel Maduabuchi
Momoh, Mumuni Audu
Akpa, Paul Achile
Ozioko, Angela Chizoba

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-06-06

Country of Publication

Egypt

No. of Pages

18

Main Subjects

Medicine

Abstract EN

The aim of this study was to investigate the potential of microparticles based on biocompatible phytolipids [Softisan® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol- (PEG-) 4000 to improve intravaginal delivery of miconazole nitrate (MN) for effective treatment of vulvovaginal candidiasis (VVC).

Lipid matrices (LMs) consisting of rational blends of SF and SO with or without PEG-4000 were prepared by fusion and characterized and employed to formulate MN-loaded solid lipid microparticles (SLMs) by melt-homogenization.

The SLMs were characterized for physicochemical properties, anticandidal activity, and stability.

Spherical discrete microparticles with good physicochemical properties and mean diameters suitable for vaginal drug delivery were obtained.

Formulations based on SO:SF (1:9) and containing highest concentrations of PEG-4000 (4 %w/w) and MN (3.0 %w/w) were stable and gave highest encapsulation efficiency (83.05–87.75%) and inhibition zone diameter (25.87±0.94–26.33±0.94 mm) and significantly (p<0.05) faster and more powerful fungicidal activity regarding killing rate constant values (7.10 x 10−3–1.09 x 10−2 min−1) than commercial topical solution of MN (Fungusol®) (8.00 x 10−3 min−1) and pure MN sample (5.160 x 10−3 min−1).

This study has shown that MN-loaded SLMs based on molecularly PEGylated lipid matrices could provide a better option to deal with VVC.

American Psychological Association (APA)

Kenechukwu, Franklin Chimaobi& Attama, Anthony Amaechi& Ibezim, Emmanuel Chinedum& Nnamani, Petra Obioma& Umeyor, Chukwuebuka Emmanuel& Uronnachi, Emmanuel Maduabuchi…[et al.]. 2018. Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate. BioMed Research International،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1126035

Modern Language Association (MLA)

Kenechukwu, Franklin Chimaobi…[et al.]. Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate. BioMed Research International No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1126035

American Medical Association (AMA)

Kenechukwu, Franklin Chimaobi& Attama, Anthony Amaechi& Ibezim, Emmanuel Chinedum& Nnamani, Petra Obioma& Umeyor, Chukwuebuka Emmanuel& Uronnachi, Emmanuel Maduabuchi…[et al.]. Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1126035

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1126035