Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin
المؤلفون المشاركون
Wang, Yan
Li, Diyan
Chen, Yuqi
Han, Shunshun
Zhao, Xiaoling
Yin, Huadong
Zhu, Qing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
T-2 toxin is a trichothecene mycotoxin produced by fungi which are known to contaminate cereals, especially in wheat and corn.
T-2 toxin is known to cause a range of toxic effects in humans and animals, including immunosuppression and carcinogenesis.
Although the effects of T-2 toxin on condition of chickens’ spleens have been reported, there has been no systematic study of damage to the spleen of broiler chickens exposed to T-2 toxin.
The purpose of the present study was to assess the effects of T-2 toxin on pathology, rates of apoptosis, oxidative stress, and T-lymphocyte subsets in the spleen of broiler chickens.
One hundred and twenty male broiler chickens were randomly assigned to one of four groups (30 birds per group), fed 0 mg/kg (control), 0.5 mg/kg, 1 mg/kg, or 2 mg/kg T-2 toxin, respectively.
After 21 days, chickens exposed to T-2 toxin demonstrated decreased relative weight and size of the spleen, increased percentage of apoptotic splenocytes, and evident lesions.
Concentrations of reactive oxygen species and MDA content increased in splenocytes during T-2 toxin treatments, whereas activities of SOD, CAT, and GSH-PX decreased.
The ratio of CD4+/CD8+ T cells also decreased as the dose of T-2 toxin increased.
Overall, these results suggest that T-2 toxin causes oxidative stress, leading to increased rates of splenocyte apoptosis and might impair the splenic immune function of broiler chickens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yuqi& Han, Shunshun& Wang, Yan& Li, Diyan& Zhao, Xiaoling& Zhu, Qing…[et al.]. 2019. Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126085
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yuqi…[et al.]. Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126085
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yuqi& Han, Shunshun& Wang, Yan& Li, Diyan& Zhao, Xiaoling& Zhu, Qing…[et al.]. Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126085
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126085
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر