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Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin
Joint Authors
Wang, Yan
Li, Diyan
Chen, Yuqi
Han, Shunshun
Zhao, Xiaoling
Yin, Huadong
Zhu, Qing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
T-2 toxin is a trichothecene mycotoxin produced by fungi which are known to contaminate cereals, especially in wheat and corn.
T-2 toxin is known to cause a range of toxic effects in humans and animals, including immunosuppression and carcinogenesis.
Although the effects of T-2 toxin on condition of chickens’ spleens have been reported, there has been no systematic study of damage to the spleen of broiler chickens exposed to T-2 toxin.
The purpose of the present study was to assess the effects of T-2 toxin on pathology, rates of apoptosis, oxidative stress, and T-lymphocyte subsets in the spleen of broiler chickens.
One hundred and twenty male broiler chickens were randomly assigned to one of four groups (30 birds per group), fed 0 mg/kg (control), 0.5 mg/kg, 1 mg/kg, or 2 mg/kg T-2 toxin, respectively.
After 21 days, chickens exposed to T-2 toxin demonstrated decreased relative weight and size of the spleen, increased percentage of apoptotic splenocytes, and evident lesions.
Concentrations of reactive oxygen species and MDA content increased in splenocytes during T-2 toxin treatments, whereas activities of SOD, CAT, and GSH-PX decreased.
The ratio of CD4+/CD8+ T cells also decreased as the dose of T-2 toxin increased.
Overall, these results suggest that T-2 toxin causes oxidative stress, leading to increased rates of splenocyte apoptosis and might impair the splenic immune function of broiler chickens.
American Psychological Association (APA)
Chen, Yuqi& Han, Shunshun& Wang, Yan& Li, Diyan& Zhao, Xiaoling& Zhu, Qing…[et al.]. 2019. Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126085
Modern Language Association (MLA)
Chen, Yuqi…[et al.]. Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126085
American Medical Association (AMA)
Chen, Yuqi& Han, Shunshun& Wang, Yan& Li, Diyan& Zhao, Xiaoling& Zhu, Qing…[et al.]. Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126085