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Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice
المؤلفون المشاركون
Tounsi, S.
Zouari Bouassida, Karama
Makni, Samar
Tounsi, Amina
Jlaiel, Lobna
Trigui, Mohamed
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Juniperus phoenicea (J.
phoenicea) is a wild tree belonging to the Cupressaceae family, commonly used for the treatment of several disorders.
This study aimed to evaluate the potential protective effects of J.
phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pain in mice models.
For the purpose, chemical compounds of J.
phoenicea EtOH-H2OE were also analyzed by GC-MS.
The J.
phoenicea EtOH-H2OE showed a potent antioxidant activity in vitro, thanks to its richness in phenolic and flavonoid compounds.
Mice treated with EtOH-H2OE (100 mg/kg BW) showed reduced paw oedema formation and decreased malondialdehyde (MDA) content.
The evaluation of antioxidant enzyme activities in paw oedema tissue after five hours of carrageenan induction showed a significant increase (P<0.05).
Inflammatory biomarkers explorations of J.
phoenicea EtOH-H2OE-treated mice showed a restoration of the studied parameters to near-normal values.
Furthermore, EtOH-H2OE of J.
phoenicea produced a significant reduction of the number of abdominal writhes (P<0.05) in a dose-dependent way.
Phytochemical analysis of the J.
phoenicea EtOH-H2OE by GC-MS showed the presence of hexadecanoic and stearic acids known as anti-inflammatory and analgesic compounds.
Our investigation provided evidence that J.
phoenicea EtOH-H2OE can effectively reduce the inflammation and pain in mice models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zouari Bouassida, Karama& Makni, Samar& Tounsi, Amina& Jlaiel, Lobna& Trigui, Mohamed& Tounsi, S.. 2018. Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zouari Bouassida, Karama…[et al.]. Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1126092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zouari Bouassida, Karama& Makni, Samar& Tounsi, Amina& Jlaiel, Lobna& Trigui, Mohamed& Tounsi, S.. Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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