Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice
Joint Authors
Tounsi, S.
Zouari Bouassida, Karama
Makni, Samar
Tounsi, Amina
Jlaiel, Lobna
Trigui, Mohamed
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Juniperus phoenicea (J.
phoenicea) is a wild tree belonging to the Cupressaceae family, commonly used for the treatment of several disorders.
This study aimed to evaluate the potential protective effects of J.
phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pain in mice models.
For the purpose, chemical compounds of J.
phoenicea EtOH-H2OE were also analyzed by GC-MS.
The J.
phoenicea EtOH-H2OE showed a potent antioxidant activity in vitro, thanks to its richness in phenolic and flavonoid compounds.
Mice treated with EtOH-H2OE (100 mg/kg BW) showed reduced paw oedema formation and decreased malondialdehyde (MDA) content.
The evaluation of antioxidant enzyme activities in paw oedema tissue after five hours of carrageenan induction showed a significant increase (P<0.05).
Inflammatory biomarkers explorations of J.
phoenicea EtOH-H2OE-treated mice showed a restoration of the studied parameters to near-normal values.
Furthermore, EtOH-H2OE of J.
phoenicea produced a significant reduction of the number of abdominal writhes (P<0.05) in a dose-dependent way.
Phytochemical analysis of the J.
phoenicea EtOH-H2OE by GC-MS showed the presence of hexadecanoic and stearic acids known as anti-inflammatory and analgesic compounds.
Our investigation provided evidence that J.
phoenicea EtOH-H2OE can effectively reduce the inflammation and pain in mice models.
American Psychological Association (APA)
Zouari Bouassida, Karama& Makni, Samar& Tounsi, Amina& Jlaiel, Lobna& Trigui, Mohamed& Tounsi, S.. 2018. Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126092
Modern Language Association (MLA)
Zouari Bouassida, Karama…[et al.]. Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1126092
American Medical Association (AMA)
Zouari Bouassida, Karama& Makni, Samar& Tounsi, Amina& Jlaiel, Lobna& Trigui, Mohamed& Tounsi, S.. Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126092