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Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses
المؤلفون المشاركون
Luo, Zhenchao
Peng, Qing
Gao, Yi
Yin, Liang-Chun
Gao, Yan-Xin
Li, Yang
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is one of the leading malignancies worldwide.
Enumeration of circulating tumor cells (CTCs) has been demonstrated to be a prognostic indicator in HCC.
Twist plays a critical role in metastasis and has been proposed as a biomarker for epithelial-mesenchymal transition (EMT).
However, links between the expression of Twist in CTCs and HCC clinical parameters are still unclear.
This study aims to evaluate the relationship between Twist expression in CTCs and clinicohistopathological risk factors of HCC.
Between June 2015 and July 2017, 80 HCC patients and 10 healthy volunteers were enrolled in this study.
CTCs were isolated and analyzed by the optimized CanPatrol™ CTC-enrichment technique.
Our analysis showed that Twist+ CTCs were detected in 54 of the 80 (67.5%) HCC patients.
The positive ratios of Twist+ CTCs correlated with portal vein tumor thrombi, TNM staging, AFP, cirrhosis, tumor number, tumor size, and microvascular invasion.
Meanwhile, the follow-up results of the 33 HCC patients who underwent hepatectomy showed that the positive ratios of Twist+ CTCs were closely correlated with the rate of metastasis or recurrence and the mortality rate.
The ROC curve analyses suggested that the prognostic evaluation of Twist+ CTCs outperforms CTCs alone.
Twist+ CTCs showed higher expression in Glypican-3 protein.
In conclusion, Twist expression in CTCs could serve as a biomarker for evaluating HCC metastasis and prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yin, Liang-Chun& Luo, Zhenchao& Gao, Yan-Xin& Li, Yang& Peng, Qing& Gao, Yi. 2018. Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126095
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yin, Liang-Chun…[et al.]. Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1126095
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yin, Liang-Chun& Luo, Zhenchao& Gao, Yan-Xin& Li, Yang& Peng, Qing& Gao, Yi. Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126095
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126095
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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