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Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses
Joint Authors
Luo, Zhenchao
Peng, Qing
Gao, Yi
Yin, Liang-Chun
Gao, Yan-Xin
Li, Yang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is one of the leading malignancies worldwide.
Enumeration of circulating tumor cells (CTCs) has been demonstrated to be a prognostic indicator in HCC.
Twist plays a critical role in metastasis and has been proposed as a biomarker for epithelial-mesenchymal transition (EMT).
However, links between the expression of Twist in CTCs and HCC clinical parameters are still unclear.
This study aims to evaluate the relationship between Twist expression in CTCs and clinicohistopathological risk factors of HCC.
Between June 2015 and July 2017, 80 HCC patients and 10 healthy volunteers were enrolled in this study.
CTCs were isolated and analyzed by the optimized CanPatrol™ CTC-enrichment technique.
Our analysis showed that Twist+ CTCs were detected in 54 of the 80 (67.5%) HCC patients.
The positive ratios of Twist+ CTCs correlated with portal vein tumor thrombi, TNM staging, AFP, cirrhosis, tumor number, tumor size, and microvascular invasion.
Meanwhile, the follow-up results of the 33 HCC patients who underwent hepatectomy showed that the positive ratios of Twist+ CTCs were closely correlated with the rate of metastasis or recurrence and the mortality rate.
The ROC curve analyses suggested that the prognostic evaluation of Twist+ CTCs outperforms CTCs alone.
Twist+ CTCs showed higher expression in Glypican-3 protein.
In conclusion, Twist expression in CTCs could serve as a biomarker for evaluating HCC metastasis and prognosis.
American Psychological Association (APA)
Yin, Liang-Chun& Luo, Zhenchao& Gao, Yan-Xin& Li, Yang& Peng, Qing& Gao, Yi. 2018. Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126095
Modern Language Association (MLA)
Yin, Liang-Chun…[et al.]. Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1126095
American Medical Association (AMA)
Yin, Liang-Chun& Luo, Zhenchao& Gao, Yan-Xin& Li, Yang& Peng, Qing& Gao, Yi. Twist Expression in Circulating Hepatocellular Carcinoma Cells Predicts Metastasis and Prognoses. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126095