Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy
المؤلفون المشاركون
Lu, Tianfei
Hao, Jun
Shen, Chuan
Gu, Guangxiang
Zhang, Jianjun
Xu, Ning
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Liver regeneration after partial hepatectomy (PH) is a highly orchestrated biological process in which synchronized hepatocyte proliferation is induced after massive liver mass loss.
Hepatocyte proliferation could be regulated by multiple signals, such as miRNAs and autophagy, but underlying mechanism remains unclear.
Here a functional miRNA during liver regeneration was identified and its underlying mechanism was delineated in vitro and in vivo.
We found that miR-1907 was highly upregulated during liver regeneration after 2/3 PH at various timepoints.
The level of miR-1907 was also increased in normal liver cell line treated with HGF at different concentrations.
Functionally, miR-1907 enhanced hepatocyte proliferation in vitro and in vivo, and the liver/body weight ratio in miR-1907-overexpressed mice was significantly higher in comparison to the control mice after 2/3 PH.
Forced expression of miR-1907 promoted autophagy activation of hepatocyte.
Importantly, autophagy inhibition significantly attenuated miR-1907-induced hepatocyte proliferation and the liver/body weight ratio.
Finally, GSK3β, a suppressor of autophagy signaling, was identified as the direct target gene of miR-1907.
Taken together, miR-1907 accelerates hepatocyte proliferation during liver regeneration by activating autophagy; thus pharmacological intervention regulating miR-1907/autophagy axis may be therapeutically beneficial in liver transplantation and liver failure by inducing liver regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Tianfei& Hao, Jun& Shen, Chuan& Gu, Guangxiang& Zhang, Jianjun& Xu, Ning. 2018. Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126123
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Tianfei…[et al.]. Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126123
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Tianfei& Hao, Jun& Shen, Chuan& Gu, Guangxiang& Zhang, Jianjun& Xu, Ning. Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126123
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126123
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر