Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy
Joint Authors
Lu, Tianfei
Hao, Jun
Shen, Chuan
Gu, Guangxiang
Zhang, Jianjun
Xu, Ning
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liver regeneration after partial hepatectomy (PH) is a highly orchestrated biological process in which synchronized hepatocyte proliferation is induced after massive liver mass loss.
Hepatocyte proliferation could be regulated by multiple signals, such as miRNAs and autophagy, but underlying mechanism remains unclear.
Here a functional miRNA during liver regeneration was identified and its underlying mechanism was delineated in vitro and in vivo.
We found that miR-1907 was highly upregulated during liver regeneration after 2/3 PH at various timepoints.
The level of miR-1907 was also increased in normal liver cell line treated with HGF at different concentrations.
Functionally, miR-1907 enhanced hepatocyte proliferation in vitro and in vivo, and the liver/body weight ratio in miR-1907-overexpressed mice was significantly higher in comparison to the control mice after 2/3 PH.
Forced expression of miR-1907 promoted autophagy activation of hepatocyte.
Importantly, autophagy inhibition significantly attenuated miR-1907-induced hepatocyte proliferation and the liver/body weight ratio.
Finally, GSK3β, a suppressor of autophagy signaling, was identified as the direct target gene of miR-1907.
Taken together, miR-1907 accelerates hepatocyte proliferation during liver regeneration by activating autophagy; thus pharmacological intervention regulating miR-1907/autophagy axis may be therapeutically beneficial in liver transplantation and liver failure by inducing liver regeneration.
American Psychological Association (APA)
Lu, Tianfei& Hao, Jun& Shen, Chuan& Gu, Guangxiang& Zhang, Jianjun& Xu, Ning. 2018. Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126123
Modern Language Association (MLA)
Lu, Tianfei…[et al.]. Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126123
American Medical Association (AMA)
Lu, Tianfei& Hao, Jun& Shen, Chuan& Gu, Guangxiang& Zhang, Jianjun& Xu, Ning. Partial Hepatectomy-Induced Upregulation of miR-1907 Accelerates Liver Regeneration by Activation Autophagy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126123