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Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma
المؤلفون المشاركون
Chen, Wen-ming
Zhang, Yue
Chen, Xiao-Lei
Zhou, He-Bing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
To establish a nomogram for predicting the overall survival (OS) of patients with newly diagnosed multiple myeloma (MM), 304 patients with newly diagnosed MM were recruited between June 1, 2010, and June 30, 2015, from the Beijing Chaoyang Hospital, Capital Medical University, and randomly divided into training (n=214) and validation (n=90) cohorts.
The Kaplan-Meier method and the Cox proportional hazards regression model were used to evaluate the prognostic effects of multiple clinical and laboratory parameters on survival.
Significant prognostic factors were combined to build a nomogram.
The discriminative ability and predictive accuracy of the nomogram were evaluated using the index of concordance (C-index) and calibration curves and compared with the five staging systems currently used for MM.
Multivariate analysis of the training cohort revealed that the age at diagnosis, clonal bone marrow plasma cells, serum lactate dehydrogenase, serum β2-microglobulin, and del (17p) were independent risk factors for OS and were used to establish the nomogram.
The C-index value of the nomogram for predicting OS was 0.749, which was significantly higher than the C-indices of the five most common staging systems currently used for MM.
In the validation cohort, the C-index for nomogram-based predictions was 0.711 for OS, and the nomogram discrimination was better than the above mentioned five staging systems (P<0.001).
All calibration curves revealed good consistency between predicted and actual survivals.
The proposed nomogram is more accurate in predicting the prognoses of patients with newly diagnosed MM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yue& Chen, Xiao-Lei& Chen, Wen-ming& Zhou, He-Bing. 2019. Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126133
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yue…[et al.]. Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1126133
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yue& Chen, Xiao-Lei& Chen, Wen-ming& Zhou, He-Bing. Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126133
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126133
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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