Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma
Joint Authors
Chen, Wen-ming
Zhang, Yue
Chen, Xiao-Lei
Zhou, He-Bing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To establish a nomogram for predicting the overall survival (OS) of patients with newly diagnosed multiple myeloma (MM), 304 patients with newly diagnosed MM were recruited between June 1, 2010, and June 30, 2015, from the Beijing Chaoyang Hospital, Capital Medical University, and randomly divided into training (n=214) and validation (n=90) cohorts.
The Kaplan-Meier method and the Cox proportional hazards regression model were used to evaluate the prognostic effects of multiple clinical and laboratory parameters on survival.
Significant prognostic factors were combined to build a nomogram.
The discriminative ability and predictive accuracy of the nomogram were evaluated using the index of concordance (C-index) and calibration curves and compared with the five staging systems currently used for MM.
Multivariate analysis of the training cohort revealed that the age at diagnosis, clonal bone marrow plasma cells, serum lactate dehydrogenase, serum β2-microglobulin, and del (17p) were independent risk factors for OS and were used to establish the nomogram.
The C-index value of the nomogram for predicting OS was 0.749, which was significantly higher than the C-indices of the five most common staging systems currently used for MM.
In the validation cohort, the C-index for nomogram-based predictions was 0.711 for OS, and the nomogram discrimination was better than the above mentioned five staging systems (P<0.001).
All calibration curves revealed good consistency between predicted and actual survivals.
The proposed nomogram is more accurate in predicting the prognoses of patients with newly diagnosed MM.
American Psychological Association (APA)
Zhang, Yue& Chen, Xiao-Lei& Chen, Wen-ming& Zhou, He-Bing. 2019. Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126133
Modern Language Association (MLA)
Zhang, Yue…[et al.]. Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1126133
American Medical Association (AMA)
Zhang, Yue& Chen, Xiao-Lei& Chen, Wen-ming& Zhou, He-Bing. Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126133