![](/images/graphics-bg.png)
A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned MediumChitosanCollagenβ-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice
المؤلفون المشاركون
Zhou, Panpan
Li, Xue
Zhang, Bing
Shi, Qing
Li, Dong
Ju, Xiuli
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-02
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
We investigated the effects of a human umbilical cord mesenchymal stem cell-conditioned medium (MSC-CM)/chitosan/collagen/β-glycerophosphate (β-GP) thermosensitive hydrogel (MSC-CM/hydrogel) on mice with third-degree burns.
MSC-CM was collected and mixed with chitosan, collagen, and β-GP to generate the thermosensitive MSC-CM/hydrogel, which was stored in the liquid phase at 4°C.
The wounds of established third-degree burned mice were then externally covered with the MSC-CM/hydrogel, which formed a gel when placed on the wounds at physiological temperature.
Injured mice in three additional groups were treated with unconditioned MSC medium (UM), MSC-CM, or UM/chitosan/collagen/β-GP thermosensitive hydrogels.
Skin wound samples were obtained 4, 14, and 28 days after burning for further analysis by hematoxylin and eosin and Ki-67 staining.
Wound healing rates and times, in addition to immunohistochemical results, were then compared and analyzed among the four groups.
Application of the MSC-CM/hydrogel shortened healing time, limited the area of inflammation, enhanced reepithelialization, promoted the formation of high-quality, well-vascularized granulation tissue, and attenuated the formation of fibrotic and hypertrophic scar tissue.
In summary, MSC-CM/hydrogel effectively promotes wound healing in third-degree burned mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Panpan& Li, Xue& Zhang, Bing& Shi, Qing& Li, Dong& Ju, Xiuli. 2019. A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned MediumChitosanCollagenβ-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1126246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Panpan…[et al.]. A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned MediumChitosanCollagenβ-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1126246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Panpan& Li, Xue& Zhang, Bing& Shi, Qing& Li, Dong& Ju, Xiuli. A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned MediumChitosanCollagenβ-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1126246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)