A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans
المؤلفون المشاركون
Wang, Shengqin
Li, Na
Li, Nan
Zou, Huixi
Wu, Mingjiang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Obesity is intrinsically linked with the gut microbiome, and studies have identified several obesity-associated microbes.
The microbe-microbe interactions can alter the composition of the microbial community and influence host health by producing secondary metabolites (SMs).
However, the contribution of these SMs in the prevention and treatment of obesity has been largely ignored.
We identified several SM-encoding biosynthetic gene clusters (BGCs) from the metagenomic data of lean and obese individuals and found significant association between some BGCs, including those that produce hitherto unknown SM, and obesity.
In addition, the mean abundance of BGCs was positively correlated with obesity, consistent with the lower taxonomic diversity in the gut microbiota of obese individuals.
By comparing the BGCs of known SM between obese and nonobese samples, we found that menaquinone produced by Enterobacter cloacae showed the highest correlation with BMI, in agreement with a recent study on human adipose tissue composition.
Furthermore, an obesity-related nonribosomal peptide synthetase (NRPS) was negatively associated with Bacteroidetes, indicating that the SMs produced by intestinal microbes in obese individuals can change the microbiome structure.
This is the first systemic study of the association between gut microbiome BGCs and obesity and provides new insights into the causes of obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shengqin& Li, Na& Li, Nan& Zou, Huixi& Wu, Mingjiang. 2019. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126690
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shengqin…[et al.]. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1126690
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shengqin& Li, Na& Li, Nan& Zou, Huixi& Wu, Mingjiang. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126690
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126690
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر