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A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans
Joint Authors
Wang, Shengqin
Li, Na
Li, Nan
Zou, Huixi
Wu, Mingjiang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity is intrinsically linked with the gut microbiome, and studies have identified several obesity-associated microbes.
The microbe-microbe interactions can alter the composition of the microbial community and influence host health by producing secondary metabolites (SMs).
However, the contribution of these SMs in the prevention and treatment of obesity has been largely ignored.
We identified several SM-encoding biosynthetic gene clusters (BGCs) from the metagenomic data of lean and obese individuals and found significant association between some BGCs, including those that produce hitherto unknown SM, and obesity.
In addition, the mean abundance of BGCs was positively correlated with obesity, consistent with the lower taxonomic diversity in the gut microbiota of obese individuals.
By comparing the BGCs of known SM between obese and nonobese samples, we found that menaquinone produced by Enterobacter cloacae showed the highest correlation with BMI, in agreement with a recent study on human adipose tissue composition.
Furthermore, an obesity-related nonribosomal peptide synthetase (NRPS) was negatively associated with Bacteroidetes, indicating that the SMs produced by intestinal microbes in obese individuals can change the microbiome structure.
This is the first systemic study of the association between gut microbiome BGCs and obesity and provides new insights into the causes of obesity.
American Psychological Association (APA)
Wang, Shengqin& Li, Na& Li, Nan& Zou, Huixi& Wu, Mingjiang. 2019. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126690
Modern Language Association (MLA)
Wang, Shengqin…[et al.]. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1126690
American Medical Association (AMA)
Wang, Shengqin& Li, Na& Li, Nan& Zou, Huixi& Wu, Mingjiang. A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126690