The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets
المؤلفون المشاركون
Grzanka, Dariusz
Gagat, Maciej
Izdebska, Magdalena
Zielińska, Wioletta
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Metastasis causes death of 90% of cancer patients, so it is the most significant issue associated with cancer disease.
Thus, it is no surprise that many researchers are trying to develop drugs targeting or preventing them.
The secondary tumour site formation is closely related to phenomena like epithelial-to-mesenchymal and its reverse, mesenchymal-to-epithelial transition.
The change of the cells’ phenotype to mesenchymal involves the acquisition of migratory potential.
Cancer cells movement is possible due to the development of invasive structures like invadopodia, lamellipodia, and filopodia.
These changes are dependent on the reorganization of the actin cytoskeleton.
In turn, the polymerization and depolymerization of actin are controlled by actin-binding proteins.
In many tumour cells, the actin and actin-associated proteins are accumulated in the cell nucleus, suggesting that it may also affect the progression of cancer by regulating gene expression.
Once the cancer cell reaches a new habitat it again acquires epithelial features and thus proliferative activity.
Targeting of epithelial-to-mesenchymal or/and mesenchymal-to-epithelial transitions through regulation of their main components expression may be a potential solution to the problem of metastasis.
This work focuses on the role of these processes in tumour progression and the assessment of therapeutic potential of agents targeting them.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Izdebska, Magdalena& Zielińska, Wioletta& Grzanka, Dariusz& Gagat, Maciej. 2018. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Izdebska, Magdalena…[et al.]. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Izdebska, Magdalena& Zielińska, Wioletta& Grzanka, Dariusz& Gagat, Maciej. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126754
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر