The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets
Joint Authors
Grzanka, Dariusz
Gagat, Maciej
Izdebska, Magdalena
Zielińska, Wioletta
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Metastasis causes death of 90% of cancer patients, so it is the most significant issue associated with cancer disease.
Thus, it is no surprise that many researchers are trying to develop drugs targeting or preventing them.
The secondary tumour site formation is closely related to phenomena like epithelial-to-mesenchymal and its reverse, mesenchymal-to-epithelial transition.
The change of the cells’ phenotype to mesenchymal involves the acquisition of migratory potential.
Cancer cells movement is possible due to the development of invasive structures like invadopodia, lamellipodia, and filopodia.
These changes are dependent on the reorganization of the actin cytoskeleton.
In turn, the polymerization and depolymerization of actin are controlled by actin-binding proteins.
In many tumour cells, the actin and actin-associated proteins are accumulated in the cell nucleus, suggesting that it may also affect the progression of cancer by regulating gene expression.
Once the cancer cell reaches a new habitat it again acquires epithelial features and thus proliferative activity.
Targeting of epithelial-to-mesenchymal or/and mesenchymal-to-epithelial transitions through regulation of their main components expression may be a potential solution to the problem of metastasis.
This work focuses on the role of these processes in tumour progression and the assessment of therapeutic potential of agents targeting them.
American Psychological Association (APA)
Izdebska, Magdalena& Zielińska, Wioletta& Grzanka, Dariusz& Gagat, Maciej. 2018. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126754
Modern Language Association (MLA)
Izdebska, Magdalena…[et al.]. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126754
American Medical Association (AMA)
Izdebska, Magdalena& Zielińska, Wioletta& Grzanka, Dariusz& Gagat, Maciej. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126754