Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma
المؤلفون المشاركون
Lee, Jong Wook
Eom, Ki-Seong
Lee, Seok
Kim, Hee-Je
Lim, Ji-Young
Ryu, Da-Bin
Kim, Tae Woo
Jeon, Young-Woo
Cho, Byung-Sik
Kim, Dong-Wook
Lee, Sung-Eun
Cho, Seok-Goo
Min, Woo-Sung
Min, Chang-Ki
Yoon, Jae-Ho
Kim, Yoo-Jin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this study was to explore if measurement of pretransplant circulating CD161-expressing cells, in addition to clinical risk factors, could predict mucositis and infections in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT).
To determine if CD161-expressing cells are likely to predict early complications, namely, mucositis (≥grade 3), infections, and cytomegalovirus (CMV) reactivation, we prospectively examined CD161-expressing cells (CD3+CD4+CD161+ and CD3+CD8+CD161+) in peripheral blood samples from 108 patients with MM undergoing ASCT.
After adjusting for factors identified by univariate analysis that predicted mucositis (≥grade 3), infection before engraftment, and CMV reactivation, multivariate analyses revealed that the low proportion of CD3+CD4+CD161+ cells in peripheral blood was an independent predictor of mucositis (≥grade 3) (P=0.020), infections before engraftment (P=0.014), and CMV reactivation (P=0.010).
In addition, we found that female sex and decreased glomerular filtration rate were independent factors for predicting mucositis.
Female sex and severe pulmonary comorbidity were independent factors for predicting infection before engraftment.
We found that the proportion of circulating CD3+CD4+CD161+ cells is useful for predicting the occurrence of early complications, including mucositis and infections, after ASCT in patients with MM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Sung-Eun& Lim, Ji-Young& Ryu, Da-Bin& Kim, Tae Woo& Jeon, Young-Woo& Yoon, Jae-Ho…[et al.]. 2018. Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Sung-Eun…[et al.]. Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Sung-Eun& Lim, Ji-Young& Ryu, Da-Bin& Kim, Tae Woo& Jeon, Young-Woo& Yoon, Jae-Ho…[et al.]. Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر