Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma
Joint Authors
Lee, Jong Wook
Eom, Ki-Seong
Lee, Seok
Kim, Hee-Je
Lim, Ji-Young
Ryu, Da-Bin
Kim, Tae Woo
Jeon, Young-Woo
Cho, Byung-Sik
Kim, Dong-Wook
Lee, Sung-Eun
Cho, Seok-Goo
Min, Woo-Sung
Min, Chang-Ki
Yoon, Jae-Ho
Kim, Yoo-Jin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to explore if measurement of pretransplant circulating CD161-expressing cells, in addition to clinical risk factors, could predict mucositis and infections in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT).
To determine if CD161-expressing cells are likely to predict early complications, namely, mucositis (≥grade 3), infections, and cytomegalovirus (CMV) reactivation, we prospectively examined CD161-expressing cells (CD3+CD4+CD161+ and CD3+CD8+CD161+) in peripheral blood samples from 108 patients with MM undergoing ASCT.
After adjusting for factors identified by univariate analysis that predicted mucositis (≥grade 3), infection before engraftment, and CMV reactivation, multivariate analyses revealed that the low proportion of CD3+CD4+CD161+ cells in peripheral blood was an independent predictor of mucositis (≥grade 3) (P=0.020), infections before engraftment (P=0.014), and CMV reactivation (P=0.010).
In addition, we found that female sex and decreased glomerular filtration rate were independent factors for predicting mucositis.
Female sex and severe pulmonary comorbidity were independent factors for predicting infection before engraftment.
We found that the proportion of circulating CD3+CD4+CD161+ cells is useful for predicting the occurrence of early complications, including mucositis and infections, after ASCT in patients with MM.
American Psychological Association (APA)
Lee, Sung-Eun& Lim, Ji-Young& Ryu, Da-Bin& Kim, Tae Woo& Jeon, Young-Woo& Yoon, Jae-Ho…[et al.]. 2018. Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127092
Modern Language Association (MLA)
Lee, Sung-Eun…[et al.]. Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127092
American Medical Association (AMA)
Lee, Sung-Eun& Lim, Ji-Young& Ryu, Da-Bin& Kim, Tae Woo& Jeon, Young-Woo& Yoon, Jae-Ho…[et al.]. Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127092