![](/images/graphics-bg.png)
Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee
المؤلفون المشاركون
Zhang, H.
Xu, Hao
Guo, Cui-cui
Gao, Zheng-yu
Wang, Chang-yao
Lv, Cheng-yu
Yin, Zi-yan
Wang, Ying-zhen
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Wear debris induced aseptic loosening is the leading cause of total knee arthroplasty (TKA) failure.
The complex mechanism of aseptic loosening has been a major issue for introducing effective prevention and treatment methods, so a simplified yet efficient rabbit model was established to address this concern with the use of micrometer-sized titanium particles.
20 New Zealand white rabbits were selected and divided into two groups (control = 10, study = 10).
A TKA surgery was then performed for each of them, with implantation of a titanium rod prosthesis which was coated evenly with micrometer-sized titanium in the study group and nothing in the control group, into right femoral medullary cavity.
After 12 weeks, all the animals were euthanized and X-ray analyses, H&E staining, Goldner Masson trichrome staining, Von Kossa staining, PCR, and Western blotting of some specific mRNAs and proteins in the interface membrane tissues around the prosthesis were carried out.
The implantation of a titanium rod prosthesis coated with 20 μm titanium particles into the femoral medullary cavity of rabbits caused continuous titanium particle stimulation around the prosthesis, effectively inducing osteolysis and aseptic loosening.
Titanium particle-induced macrophages produce multiple inflammatory factors able to activate osteoclast differentiation through the OPG/RANKL/RANK signaling pathway, resulting in osteolysis while suppressing the function of osteoblasts and reducing bone ingrowth around the prosthesis.
This model simulated the implantation and loosening process of an artificial prosthesis, which is an ideal etiological model to study the aseptic prosthetic loosening.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Hao& Guo, Cui-cui& Gao, Zheng-yu& Wang, Chang-yao& Zhang, H.& Lv, Cheng-yu…[et al.]. 2018. Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Hao…[et al.]. Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1127266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Hao& Guo, Cui-cui& Gao, Zheng-yu& Wang, Chang-yao& Zhang, H.& Lv, Cheng-yu…[et al.]. Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)