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Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee
Joint Authors
Zhang, H.
Xu, Hao
Guo, Cui-cui
Gao, Zheng-yu
Wang, Chang-yao
Lv, Cheng-yu
Yin, Zi-yan
Wang, Ying-zhen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Wear debris induced aseptic loosening is the leading cause of total knee arthroplasty (TKA) failure.
The complex mechanism of aseptic loosening has been a major issue for introducing effective prevention and treatment methods, so a simplified yet efficient rabbit model was established to address this concern with the use of micrometer-sized titanium particles.
20 New Zealand white rabbits were selected and divided into two groups (control = 10, study = 10).
A TKA surgery was then performed for each of them, with implantation of a titanium rod prosthesis which was coated evenly with micrometer-sized titanium in the study group and nothing in the control group, into right femoral medullary cavity.
After 12 weeks, all the animals were euthanized and X-ray analyses, H&E staining, Goldner Masson trichrome staining, Von Kossa staining, PCR, and Western blotting of some specific mRNAs and proteins in the interface membrane tissues around the prosthesis were carried out.
The implantation of a titanium rod prosthesis coated with 20 μm titanium particles into the femoral medullary cavity of rabbits caused continuous titanium particle stimulation around the prosthesis, effectively inducing osteolysis and aseptic loosening.
Titanium particle-induced macrophages produce multiple inflammatory factors able to activate osteoclast differentiation through the OPG/RANKL/RANK signaling pathway, resulting in osteolysis while suppressing the function of osteoblasts and reducing bone ingrowth around the prosthesis.
This model simulated the implantation and loosening process of an artificial prosthesis, which is an ideal etiological model to study the aseptic prosthetic loosening.
American Psychological Association (APA)
Xu, Hao& Guo, Cui-cui& Gao, Zheng-yu& Wang, Chang-yao& Zhang, H.& Lv, Cheng-yu…[et al.]. 2018. Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127266
Modern Language Association (MLA)
Xu, Hao…[et al.]. Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1127266
American Medical Association (AMA)
Xu, Hao& Guo, Cui-cui& Gao, Zheng-yu& Wang, Chang-yao& Zhang, H.& Lv, Cheng-yu…[et al.]. Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1127266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127266