Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA
المؤلفون المشاركون
Xian, Zhemin
Jin, Guangyu
Li, Hongmei
Jiang, Jingzhi
Wang, Chongyang
Zhu, Lianhua
Jin, Zhehu
Li, Liangchang
Piao, Hongmei
Zheng, Mingyu
Yan, Guanghai
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study is to investigate the effects of imperatorin (IMP) on allergic responses mediated by mast cells, both in vitro and in vivo.
Passive cutaneous anaphylaxis (PCA) model was established.
Histological detection was performed to assess the ear histology.
ELISA and Western blot analysis were used to detect the levels of corresponding cytokines and signalling pathway proteins.
IMP decreased the leakage of Evans blue and the ear thickness in the PCA models, in a dose-dependent manner, and alleviated the degranulation of mast cells.
Moreover, IMP reduced the expression of TNF-α, IL-4, IL-1β, IL-8, and IL-13.
Furthermore, IMP inhibited the phosphorylation levels of Syk, Lyn, PLC-γ1, and Gab2, as well as the downstream MAPK, PI3K/AKT, and NF-κB signaling pathways.
In addition, IMP inhibited the mast cell-mediated allergic responses through the Nrf2/HO-1 pathway.
IMP attenuates the allergic responses through inhibiting the degranulation and decreasing the expression levels of proinflammatory cytokines in the mast cells, involving the PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1 pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xian, Zhemin& Jin, Guangyu& Li, Hongmei& Jiang, Jingzhi& Wang, Chongyang& Zhu, Lianhua…[et al.]. 2019. Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xian, Zhemin…[et al.]. Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1127560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xian, Zhemin& Jin, Guangyu& Li, Hongmei& Jiang, Jingzhi& Wang, Chongyang& Zhu, Lianhua…[et al.]. Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127560
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر