Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA
Joint Authors
Xian, Zhemin
Jin, Guangyu
Li, Hongmei
Jiang, Jingzhi
Wang, Chongyang
Zhu, Lianhua
Jin, Zhehu
Li, Liangchang
Piao, Hongmei
Zheng, Mingyu
Yan, Guanghai
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study is to investigate the effects of imperatorin (IMP) on allergic responses mediated by mast cells, both in vitro and in vivo.
Passive cutaneous anaphylaxis (PCA) model was established.
Histological detection was performed to assess the ear histology.
ELISA and Western blot analysis were used to detect the levels of corresponding cytokines and signalling pathway proteins.
IMP decreased the leakage of Evans blue and the ear thickness in the PCA models, in a dose-dependent manner, and alleviated the degranulation of mast cells.
Moreover, IMP reduced the expression of TNF-α, IL-4, IL-1β, IL-8, and IL-13.
Furthermore, IMP inhibited the phosphorylation levels of Syk, Lyn, PLC-γ1, and Gab2, as well as the downstream MAPK, PI3K/AKT, and NF-κB signaling pathways.
In addition, IMP inhibited the mast cell-mediated allergic responses through the Nrf2/HO-1 pathway.
IMP attenuates the allergic responses through inhibiting the degranulation and decreasing the expression levels of proinflammatory cytokines in the mast cells, involving the PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1 pathways.
American Psychological Association (APA)
Xian, Zhemin& Jin, Guangyu& Li, Hongmei& Jiang, Jingzhi& Wang, Chongyang& Zhu, Lianhua…[et al.]. 2019. Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127560
Modern Language Association (MLA)
Xian, Zhemin…[et al.]. Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1127560
American Medical Association (AMA)
Xian, Zhemin& Jin, Guangyu& Li, Hongmei& Jiang, Jingzhi& Wang, Chongyang& Zhu, Lianhua…[et al.]. Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127560