De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy
المؤلفون المشاركون
Lee, Wei-Chen
Lee, Chen-Fang
Wu, Tsung-Han
Wu, Ting-Jung
Chou, Hong-Shiue
Chan, Kun-Ming
Cheng, Chih-Hsien
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Clinically severe infection-related inflammation after major liver resection may cause hyperbilirubinemia.
This study aims to clarify the impact of bacterial infection and endotoxins on the hepatobiliary transporter system and to explore possible mechanisms of endotoxin-related postoperative hyperbilirubinemia.
Method.
Mice that underwent major hepatectomy with removal of at least 70% of liver volume were exposed to lipopolysaccharide (LPS) at different dosages.
Subsequently, hepatobiliary transporter compounds related to bile salt excretion were further investigated.
Results.
The expression of genes related to hepatobiliary transporter compounds was not significantly different in the liver tissue of mice after major hepatectomy and LPS exposure.
However, bile salt export pump (BSEP) protein expression within the liver tissue of mice treated with LPS after major hepatectomy was relatively weaker and was even further reduced in the high-dose LPS group.
The formation of antibodies against the BSEP in response to endotoxin exposure was also detected.
Conclusion.
This study illustrates a possible mechanism whereby the dysfunction of hepatobiliary transporter systems caused by endotoxin-induced autoantibodies may be involved in the development of postoperative jaundice associated with bacterial infection after major hepatectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chan, Kun-Ming& Cheng, Chih-Hsien& Wu, Tsung-Han& Lee, Chen-Fang& Wu, Ting-Jung& Chou, Hong-Shiue…[et al.]. 2018. De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chan, Kun-Ming…[et al.]. De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chan, Kun-Ming& Cheng, Chih-Hsien& Wu, Tsung-Han& Lee, Chen-Fang& Wu, Ting-Jung& Chou, Hong-Shiue…[et al.]. De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر