De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy
Joint Authors
Lee, Wei-Chen
Lee, Chen-Fang
Wu, Tsung-Han
Wu, Ting-Jung
Chou, Hong-Shiue
Chan, Kun-Ming
Cheng, Chih-Hsien
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Clinically severe infection-related inflammation after major liver resection may cause hyperbilirubinemia.
This study aims to clarify the impact of bacterial infection and endotoxins on the hepatobiliary transporter system and to explore possible mechanisms of endotoxin-related postoperative hyperbilirubinemia.
Method.
Mice that underwent major hepatectomy with removal of at least 70% of liver volume were exposed to lipopolysaccharide (LPS) at different dosages.
Subsequently, hepatobiliary transporter compounds related to bile salt excretion were further investigated.
Results.
The expression of genes related to hepatobiliary transporter compounds was not significantly different in the liver tissue of mice after major hepatectomy and LPS exposure.
However, bile salt export pump (BSEP) protein expression within the liver tissue of mice treated with LPS after major hepatectomy was relatively weaker and was even further reduced in the high-dose LPS group.
The formation of antibodies against the BSEP in response to endotoxin exposure was also detected.
Conclusion.
This study illustrates a possible mechanism whereby the dysfunction of hepatobiliary transporter systems caused by endotoxin-induced autoantibodies may be involved in the development of postoperative jaundice associated with bacterial infection after major hepatectomy.
American Psychological Association (APA)
Chan, Kun-Ming& Cheng, Chih-Hsien& Wu, Tsung-Han& Lee, Chen-Fang& Wu, Ting-Jung& Chou, Hong-Shiue…[et al.]. 2018. De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127756
Modern Language Association (MLA)
Chan, Kun-Ming…[et al.]. De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127756
American Medical Association (AMA)
Chan, Kun-Ming& Cheng, Chih-Hsien& Wu, Tsung-Han& Lee, Chen-Fang& Wu, Ting-Jung& Chou, Hong-Shiue…[et al.]. De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127756