Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues
المؤلفون المشاركون
Li, Weiyang
Qi, Yanwei
Cui, Xiaofang
Huo, Qing
Zhu, Liangxi
Zhang, Aiping
Tan, Meihua
Hong, Qilan
Yang, Yan
Zhang, Huali
Liu, Chuanxin
Kong, Qingsheng
Geng, Jiazheng
Tian, Yanjun
Kong, Fancong
Man, Dongmei
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
High-risk HPV is clearly associated with cervical cancer.
HPV integration has been confirmed to promote carcinogenesis in the previous studies.
In our study, a total of 285 DNA breakpoints and 287 RNA breakpoints were collected.
We analyzed the characteristic of HPV integration in the DNA and RNA samples.
The results revealed that the patterns of HPV integration in RNA and DNA samples differ significantly.
FHIT, KLF5, and LINC00392 were the hotspot genes integrated by HPV in the DNA samples.
RAD51B, CASC8, CASC21, ERBB2, TP63, TEX41, RAP2B, and MYC were the hotspot genes integrated by HPV in RNA samples.
Breakpoints of DNA samples were significantly prone to the region of INTRON (P < 0.01, Chi-squared test), whereas in the RNA samples, the breakpoints were prone to EXON.
Pathway analysis had revealed that the breakpoints of RNA samples were enriched in the pathways of transcriptional misregulation in cancer, cancer pathway, and pathway of adherens junction.
Breakpoints of DNA samples were enriched in the pathway of cholinergic synapse.
In summary, our data helped to gain insights into the HPV integration sites in DNA and RNA samples of cervical cancer.
It had provided theoretical basis for understanding the mechanism of tumorigenesis from the perspective of HPV integration in the HPV-associated cervical cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Weiyang& Qi, Yanwei& Cui, Xiaofang& Huo, Qing& Zhu, Liangxi& Zhang, Aiping…[et al.]. 2018. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127794
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Weiyang…[et al.]. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1127794
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Weiyang& Qi, Yanwei& Cui, Xiaofang& Huo, Qing& Zhu, Liangxi& Zhang, Aiping…[et al.]. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127794
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127794
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر