Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues
Joint Authors
Li, Weiyang
Qi, Yanwei
Cui, Xiaofang
Huo, Qing
Zhu, Liangxi
Zhang, Aiping
Tan, Meihua
Hong, Qilan
Yang, Yan
Zhang, Huali
Liu, Chuanxin
Kong, Qingsheng
Geng, Jiazheng
Tian, Yanjun
Kong, Fancong
Man, Dongmei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
High-risk HPV is clearly associated with cervical cancer.
HPV integration has been confirmed to promote carcinogenesis in the previous studies.
In our study, a total of 285 DNA breakpoints and 287 RNA breakpoints were collected.
We analyzed the characteristic of HPV integration in the DNA and RNA samples.
The results revealed that the patterns of HPV integration in RNA and DNA samples differ significantly.
FHIT, KLF5, and LINC00392 were the hotspot genes integrated by HPV in the DNA samples.
RAD51B, CASC8, CASC21, ERBB2, TP63, TEX41, RAP2B, and MYC were the hotspot genes integrated by HPV in RNA samples.
Breakpoints of DNA samples were significantly prone to the region of INTRON (P < 0.01, Chi-squared test), whereas in the RNA samples, the breakpoints were prone to EXON.
Pathway analysis had revealed that the breakpoints of RNA samples were enriched in the pathways of transcriptional misregulation in cancer, cancer pathway, and pathway of adherens junction.
Breakpoints of DNA samples were enriched in the pathway of cholinergic synapse.
In summary, our data helped to gain insights into the HPV integration sites in DNA and RNA samples of cervical cancer.
It had provided theoretical basis for understanding the mechanism of tumorigenesis from the perspective of HPV integration in the HPV-associated cervical cancers.
American Psychological Association (APA)
Li, Weiyang& Qi, Yanwei& Cui, Xiaofang& Huo, Qing& Zhu, Liangxi& Zhang, Aiping…[et al.]. 2018. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127794
Modern Language Association (MLA)
Li, Weiyang…[et al.]. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1127794
American Medical Association (AMA)
Li, Weiyang& Qi, Yanwei& Cui, Xiaofang& Huo, Qing& Zhu, Liangxi& Zhang, Aiping…[et al.]. Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127794