Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding
المؤلفون المشاركون
Cerami, Lillo Bruno
Setti, Tiziano
Bergamini, Ezio
Giannella, Luca
Boselli, Fausto
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To create a prediction model including clinical variables for the prediction of premalignant/malignant endometrial pathology in premenopausal women with abnormal uterine bleeding (AUB).
Methods.
This is an observational retrospective study including 240 premenopausal women with AUB referred to diagnostic hysteroscopy.
Based on the presence of endometrial hyperplasia (EH) or cancer (EC), the women were divided into cases (EH/EC) and controls (no EH/EC).
Univariate, stepwise logistic regression and ROC curve analysis were performed.
Results.
12 women had EH/EC (5%).
Stepwise logistic regression analysis showed that EH/EC associated significantly with BMI ≥ 30 (OR=7.70, 95% CI 1.90 to 31.17), diabetes (OR=9.71, 95% CI 1.63 to 57.81), and a thickened endometrium (OR=1.20, 95% CI 1.08 to 1.34, criterion > 11 mm).
The AUC was 0.854 (95% confidence intervals 0.803 to 0.896, p<0.0001).
Considering the pretest probability for EH/EC of 5%, the prediction model with a positive likelihood ratio of 8.14 showed a posttest probability of 30%.
The simultaneous presence of two or three risk factors was significantly more common in women with EH/EC than controls (50% vs.
6.6 and 25% vs.
0%, respectively, p<0.0001).
Conclusion.
When premenopausal vaginal bleeding occurs in diabetic obese women with ET > 11 mm, the percentage of premalignant/malignant endometrial pathology increases by 25%.
It is likely that the simultaneous presence of several risk factors is necessary to significantly increase the probability of endometrial pathology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giannella, Luca& Cerami, Lillo Bruno& Setti, Tiziano& Bergamini, Ezio& Boselli, Fausto. 2019. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1128019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giannella, Luca…[et al.]. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1128019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giannella, Luca& Cerami, Lillo Bruno& Setti, Tiziano& Bergamini, Ezio& Boselli, Fausto. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1128019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر