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Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding
Joint Authors
Cerami, Lillo Bruno
Setti, Tiziano
Bergamini, Ezio
Giannella, Luca
Boselli, Fausto
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To create a prediction model including clinical variables for the prediction of premalignant/malignant endometrial pathology in premenopausal women with abnormal uterine bleeding (AUB).
Methods.
This is an observational retrospective study including 240 premenopausal women with AUB referred to diagnostic hysteroscopy.
Based on the presence of endometrial hyperplasia (EH) or cancer (EC), the women were divided into cases (EH/EC) and controls (no EH/EC).
Univariate, stepwise logistic regression and ROC curve analysis were performed.
Results.
12 women had EH/EC (5%).
Stepwise logistic regression analysis showed that EH/EC associated significantly with BMI ≥ 30 (OR=7.70, 95% CI 1.90 to 31.17), diabetes (OR=9.71, 95% CI 1.63 to 57.81), and a thickened endometrium (OR=1.20, 95% CI 1.08 to 1.34, criterion > 11 mm).
The AUC was 0.854 (95% confidence intervals 0.803 to 0.896, p<0.0001).
Considering the pretest probability for EH/EC of 5%, the prediction model with a positive likelihood ratio of 8.14 showed a posttest probability of 30%.
The simultaneous presence of two or three risk factors was significantly more common in women with EH/EC than controls (50% vs.
6.6 and 25% vs.
0%, respectively, p<0.0001).
Conclusion.
When premenopausal vaginal bleeding occurs in diabetic obese women with ET > 11 mm, the percentage of premalignant/malignant endometrial pathology increases by 25%.
It is likely that the simultaneous presence of several risk factors is necessary to significantly increase the probability of endometrial pathology.
American Psychological Association (APA)
Giannella, Luca& Cerami, Lillo Bruno& Setti, Tiziano& Bergamini, Ezio& Boselli, Fausto. 2019. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1128019
Modern Language Association (MLA)
Giannella, Luca…[et al.]. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1128019
American Medical Association (AMA)
Giannella, Luca& Cerami, Lillo Bruno& Setti, Tiziano& Bergamini, Ezio& Boselli, Fausto. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1128019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128019