An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease
المؤلفون المشاركون
Duan, Hongfei
Li, Hua
Tong, Li
Wang, Jun
Liang, Qingtao
Zhang, Yun
Chu, Naihui
Chen, Xiaoyou
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Treatment response for the Mycobacterium abscessus (M.
abscessus) lung disease remains far from satisfying.
An effective regimen is needed to solve the problem.
Methods.
We retrospectively reviewed the medical records of all patients with M.
abscessus lung disease who received antibiotics regimen at Beijing Chest Hospital Affiliated to Capital Medical University between July 1, 2010, and February 1, 2018.
Patients were administered a conventional antibiotics regimen (including macrolide and moxifloxacin, along with an initial 12-week course of low-dose cefoxitin and amikacin) or intensified regimen (including a higher dosage of cefoxitin and linezolid besides conventional drugs), respectively.
The time to sputum-culture conversion and proportion of sputum-culture conversion in liquid broth were investigated to evaluate the efficacy and evaluation of safety by performing the classification of adverse events according to the Division of AIDS, National Institute of Allergy and Infectious Disease.
Patients were followed for 18 months from baseline.
Results.
In the conventional regimen group, the sputum conversion rate at 18 months was 29.4% (10/34), and the median time until sputum conversion was 2 months (IQR, 1-2 mo).
Furthermore, in the intensified regimen group, the sputum conversion rate was 81.3% (13/16), and the median time until sputum conversion was 1 month (IQR, 1-1 mo).
Leukopenia and drug-induced hepatotoxicity occurred more frequently in the intensified regimen group in contrast with the conventional regimen group patients.
However, only 1 adverse event in the intensified regimen group was classified as severe adverse event.
Conclusions.
The intensified regimen could improve sputum conversion of M.
abscessus lung disease compared with conventional regimen, but close safety surveillance is necessary to monitor adverse events.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Hua& Tong, Li& Wang, Jun& Liang, Qingtao& Zhang, Yun& Chu, Naihui…[et al.]. 2019. An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1128034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Hua…[et al.]. An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease. BioMed Research International No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1128034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Hua& Tong, Li& Wang, Jun& Liang, Qingtao& Zhang, Yun& Chu, Naihui…[et al.]. An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1128034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر