An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease

Joint Authors

Duan, Hongfei
Li, Hua
Tong, Li
Wang, Jun
Liang, Qingtao
Zhang, Yun
Chu, Naihui
Chen, Xiaoyou

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-11-19

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Background.

Treatment response for the Mycobacterium abscessus (M.

abscessus) lung disease remains far from satisfying.

An effective regimen is needed to solve the problem.

Methods.

We retrospectively reviewed the medical records of all patients with M.

abscessus lung disease who received antibiotics regimen at Beijing Chest Hospital Affiliated to Capital Medical University between July 1, 2010, and February 1, 2018.

Patients were administered a conventional antibiotics regimen (including macrolide and moxifloxacin, along with an initial 12-week course of low-dose cefoxitin and amikacin) or intensified regimen (including a higher dosage of cefoxitin and linezolid besides conventional drugs), respectively.

The time to sputum-culture conversion and proportion of sputum-culture conversion in liquid broth were investigated to evaluate the efficacy and evaluation of safety by performing the classification of adverse events according to the Division of AIDS, National Institute of Allergy and Infectious Disease.

Patients were followed for 18 months from baseline.

Results.

In the conventional regimen group, the sputum conversion rate at 18 months was 29.4% (10/34), and the median time until sputum conversion was 2 months (IQR, 1-2 mo).

Furthermore, in the intensified regimen group, the sputum conversion rate was 81.3% (13/16), and the median time until sputum conversion was 1 month (IQR, 1-1 mo).

Leukopenia and drug-induced hepatotoxicity occurred more frequently in the intensified regimen group in contrast with the conventional regimen group patients.

However, only 1 adverse event in the intensified regimen group was classified as severe adverse event.

Conclusions.

The intensified regimen could improve sputum conversion of M.

abscessus lung disease compared with conventional regimen, but close safety surveillance is necessary to monitor adverse events.

American Psychological Association (APA)

Li, Hua& Tong, Li& Wang, Jun& Liang, Qingtao& Zhang, Yun& Chu, Naihui…[et al.]. 2019. An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1128034

Modern Language Association (MLA)

Li, Hua…[et al.]. An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease. BioMed Research International No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1128034

American Medical Association (AMA)

Li, Hua& Tong, Li& Wang, Jun& Liang, Qingtao& Zhang, Yun& Chu, Naihui…[et al.]. An Intensified Regimen Containing Linezolid Could Improve Treatment Response in Mycobacterium abscessus Lung Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1128034

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128034