Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging
المؤلفون المشاركون
Li, Xuewei
Zhu, Li
Xi, Xiaoyu
Zou, Qin
Wei, Yingying
Chen, Yan
Wang, Xue
Lv, Daojun
Li, Peilin
Wen, Anxiang
Tang, Guoqing
Ma, Jideng
Li, Mingzhou
Jiang, Yanzhi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-30
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The biological function of human ovaries declines along with aging.
To identify the underlying molecular changes during ovarian aging, pigs were used as model animals.
Genome-wide DNA methylation and transcriptome-wide RNA expression analyses were performed via high-throughput sequencing of ovaries from young pigs (180 days, puberty stage of first ovulation) and old pigs (eight years, reproductive exhaustion stage).
The results identified 422 different methylation regions between old and young pigs; furthermore, a total of 2,243 mRNAs, 95 microRNAs, 248 long noncoding RNAs (lncRNAs), and 116 circular RNAs (circRNAs) were differentially expressed during both developmental stages.
Gene ontology analysis showed that these genes related to different methylation and expression are involved in the ovarian aging cycle.
Specifically, these are involved in cell apoptosis, death effector domain binding, embryonic development, reproduction and fertilization process, ovarian cumulus expansion, and the ovulation cycle.
Multigroup cooperative control relationships were also assessed, and competing endogenous RNA (ceRNA) networks were constructed in the ovarian aging cycle.
These data will help to clarify ovary age-associated potential molecular changes in DNA methylation and transcriptional patterns over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xi, Xiaoyu& Zou, Qin& Wei, Yingying& Chen, Yan& Wang, Xue& Lv, Daojun…[et al.]. 2019. Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging. BioMed Research International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1128096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xi, Xiaoyu…[et al.]. Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging. BioMed Research International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1128096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xi, Xiaoyu& Zou, Qin& Wei, Yingying& Chen, Yan& Wang, Xue& Lv, Daojun…[et al.]. Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1128096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر