Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging

Joint Authors

Li, Xuewei
Zhu, Li
Xi, Xiaoyu
Zou, Qin
Wei, Yingying
Chen, Yan
Wang, Xue
Lv, Daojun
Li, Peilin
Wen, Anxiang
Tang, Guoqing
Ma, Jideng
Li, Mingzhou
Jiang, Yanzhi

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-10-30

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Medicine

Abstract EN

The biological function of human ovaries declines along with aging.

To identify the underlying molecular changes during ovarian aging, pigs were used as model animals.

Genome-wide DNA methylation and transcriptome-wide RNA expression analyses were performed via high-throughput sequencing of ovaries from young pigs (180 days, puberty stage of first ovulation) and old pigs (eight years, reproductive exhaustion stage).

The results identified 422 different methylation regions between old and young pigs; furthermore, a total of 2,243 mRNAs, 95 microRNAs, 248 long noncoding RNAs (lncRNAs), and 116 circular RNAs (circRNAs) were differentially expressed during both developmental stages.

Gene ontology analysis showed that these genes related to different methylation and expression are involved in the ovarian aging cycle.

Specifically, these are involved in cell apoptosis, death effector domain binding, embryonic development, reproduction and fertilization process, ovarian cumulus expansion, and the ovulation cycle.

Multigroup cooperative control relationships were also assessed, and competing endogenous RNA (ceRNA) networks were constructed in the ovarian aging cycle.

These data will help to clarify ovary age-associated potential molecular changes in DNA methylation and transcriptional patterns over time.

American Psychological Association (APA)

Xi, Xiaoyu& Zou, Qin& Wei, Yingying& Chen, Yan& Wang, Xue& Lv, Daojun…[et al.]. 2019. Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging. BioMed Research International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1128096

Modern Language Association (MLA)

Xi, Xiaoyu…[et al.]. Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging. BioMed Research International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1128096

American Medical Association (AMA)

Xi, Xiaoyu& Zou, Qin& Wei, Yingying& Chen, Yan& Wang, Xue& Lv, Daojun…[et al.]. Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1128096

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128096