Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16
المؤلفون المشاركون
Wu, Chun-Yu
Cheng, Ya-Jung
Hung, Ming-Hui
Lin, I-Ju
Chan, Kuang-Cheng
Sun, Wei-Zen
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Acute respiratory distress syndrome (ARDS) after living-donor liver transplantation (LDLT) is not uncommon, but it lacks the biomarkers for early detection.
Club cell protein 16 (CC16), high-motility group box 1 protein (HMGB1), interleukin-1β (IL-1β), and IL-10 have been reported as relevant to the development of ARDS.
However, they have not been investigated during LDLT.
Methods.
Seventy-three consecutive recipients undergoing LDLT were enrolled and received the same perioperative care plan.
Perioperative serum CC16, HMGB1, IL-1β, and IL-10 levels were measured at the pretransplant state, 30 minutes after reperfusion, postoperative day 1 (POD1), and POD3.
ARDS was diagnosed according to the 2012 Berlin definition.
Results.
Of the 73 recipients, 13 developed ARDS with significantly longer durations of mechanical ventilation and intensive care unit stay.
Serum CC16 levels on POD1 increased significantly from the pretransplant state in the ARDS group but not in the non-ARDS group.
Pretransplant serum CC16 levels were also higher in the ARDS group.
The area under the receiver operating characteristic curves for POD1 serum CC16 levels used to discriminate ARDS was 0.803 (95% confidence interval: 0.679 to 0.895; p < 0.001).
By comparison, HMGB1, IL-1β, and IL-10 were not associated with ARDS after LDLT.
Conclusion.
The higher pretransplant serum CC16 level and its increased level on POD1 were associated with the development of early ARDS after LDLT.
This trial is registered with NCT01936545, 27 August 2013.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Chun-Yu& Cheng, Ya-Jung& Hung, Ming-Hui& Lin, I-Ju& Sun, Wei-Zen& Chan, Kuang-Cheng. 2019. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1128187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Chun-Yu…[et al.]. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1128187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Chun-Yu& Cheng, Ya-Jung& Hung, Ming-Hui& Lin, I-Ju& Sun, Wei-Zen& Chan, Kuang-Cheng. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1128187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر