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Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea
المؤلفون المشاركون
Tong, Jiayi
Yu, Fu-chao
Li, Yang
Wei, Qin
Li, Chen
Zhen, Penghao
Zhang, Guanghao
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is a leading factor affecting cardiovascular fibrosis.
Under IH condition, smooth muscle cells (SMAs) respond by dedifferentiation, which is associated with vascular remodelling.
The expression of prolyl 4-hydroxylase domain protein 3 (PHD3) increases under hypoxia.
However, the role of PHD3 in OSA-induced SMA dedifferentiation and cardiovascular fibrosis remains uncertain.
Methods.
We explored the mechanism of cardiovascular remodelling in C57BL/6 mice exposed to IH for 3 months and investigated the mechanism of PHD3 in improving the remodelling in vivo and vitro.
Results.
In vivo remodelling showed that IH induced cardiovascular fibrosis via SMC dedifferentiation and that fibrosis improved when PHD3 was overexpressed.
In vitro remodelling showed that IH induced SMA dedifferentiation, which secretes much collagen I.
PHD3 overexpression in cultured SMCs reversed the dedifferentiation by degrading and inactivating HIF-1α.
Conclusion.
OSA-induced cardiovascular fibrosis was associated with SMC dedifferentiation, and PHD3 overexpression may benefit its prevention by reversing the dedifferentiation.
Therefore, PHD3 overexpression has therapeutic potential in disease treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, Jiayi& Yu, Fu-chao& Li, Yang& Wei, Qin& Li, Chen& Zhen, Penghao…[et al.]. 2019. Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128358
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, Jiayi…[et al.]. Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128358
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, Jiayi& Yu, Fu-chao& Li, Yang& Wei, Qin& Li, Chen& Zhen, Penghao…[et al.]. Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128358
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128358
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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