Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea
Joint Authors
Tong, Jiayi
Yu, Fu-chao
Li, Yang
Wei, Qin
Li, Chen
Zhen, Penghao
Zhang, Guanghao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is a leading factor affecting cardiovascular fibrosis.
Under IH condition, smooth muscle cells (SMAs) respond by dedifferentiation, which is associated with vascular remodelling.
The expression of prolyl 4-hydroxylase domain protein 3 (PHD3) increases under hypoxia.
However, the role of PHD3 in OSA-induced SMA dedifferentiation and cardiovascular fibrosis remains uncertain.
Methods.
We explored the mechanism of cardiovascular remodelling in C57BL/6 mice exposed to IH for 3 months and investigated the mechanism of PHD3 in improving the remodelling in vivo and vitro.
Results.
In vivo remodelling showed that IH induced cardiovascular fibrosis via SMC dedifferentiation and that fibrosis improved when PHD3 was overexpressed.
In vitro remodelling showed that IH induced SMA dedifferentiation, which secretes much collagen I.
PHD3 overexpression in cultured SMCs reversed the dedifferentiation by degrading and inactivating HIF-1α.
Conclusion.
OSA-induced cardiovascular fibrosis was associated with SMC dedifferentiation, and PHD3 overexpression may benefit its prevention by reversing the dedifferentiation.
Therefore, PHD3 overexpression has therapeutic potential in disease treatment.
American Psychological Association (APA)
Tong, Jiayi& Yu, Fu-chao& Li, Yang& Wei, Qin& Li, Chen& Zhen, Penghao…[et al.]. 2019. Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128358
Modern Language Association (MLA)
Tong, Jiayi…[et al.]. Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128358
American Medical Association (AMA)
Tong, Jiayi& Yu, Fu-chao& Li, Yang& Wei, Qin& Li, Chen& Zhen, Penghao…[et al.]. Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128358