Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study
المؤلفون المشاركون
Zaidi, Syed S.
Ward, Ryan D.
Ramanathan, Kodangudi
Yu, Xinhua
Gladysheva, Inna P.
Reed, Guy L.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood.
Methods and Results.
This pilot study (n=48) compared plasma levels of corin, neprilysin, ANP, BNP, and cGMP in control patients with normal ejection fractions (mean EF 63 ± 3 %) versus patients with systolic dysfunction, with (EF 24 ± 8 %) and without (EF 27 ± 7 %) decompensated HF (dHF), as defined by Framingham and BNP criteria.
Mean ages, use of beta blockers, and ACE-inhibitors-angiotensin receptor blockers were similar between the groups.
Corin levels were depressed in systolic dysfunction patients ( 797 ± 346 pg/ml) versus controls ( 1188 ± 549 , p<0.02), but levels were not affected by dHF (p=0.77).
In contrast, levels of neprilysin (p<0.01), cGMP (p<0.001), and ANP (p<0.001) were higher in systolic dysfunction patients than controls and were the highest in patients with dHF.
Conclusions.
Levels of neprilysin, ANP, BNP, and cGMP increased in patients with reduced systolic function and were the highest in dHF patients.
Conversely, corin levels were low in patients with reduced EF with or without dHF.
This pattern suggests possible enzymatic downregulation of natriuretic peptide activity in patients with reduced EF, which may have diagnostic and prognostic implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaidi, Syed S.& Ward, Ryan D.& Ramanathan, Kodangudi& Yu, Xinhua& Gladysheva, Inna P.& Reed, Guy L.. 2018. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaidi, Syed S.…[et al.]. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaidi, Syed S.& Ward, Ryan D.& Ramanathan, Kodangudi& Yu, Xinhua& Gladysheva, Inna P.& Reed, Guy L.. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر