Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study
Joint Authors
Zaidi, Syed S.
Ward, Ryan D.
Ramanathan, Kodangudi
Yu, Xinhua
Gladysheva, Inna P.
Reed, Guy L.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood.
Methods and Results.
This pilot study (n=48) compared plasma levels of corin, neprilysin, ANP, BNP, and cGMP in control patients with normal ejection fractions (mean EF 63 ± 3 %) versus patients with systolic dysfunction, with (EF 24 ± 8 %) and without (EF 27 ± 7 %) decompensated HF (dHF), as defined by Framingham and BNP criteria.
Mean ages, use of beta blockers, and ACE-inhibitors-angiotensin receptor blockers were similar between the groups.
Corin levels were depressed in systolic dysfunction patients ( 797 ± 346 pg/ml) versus controls ( 1188 ± 549 , p<0.02), but levels were not affected by dHF (p=0.77).
In contrast, levels of neprilysin (p<0.01), cGMP (p<0.001), and ANP (p<0.001) were higher in systolic dysfunction patients than controls and were the highest in patients with dHF.
Conclusions.
Levels of neprilysin, ANP, BNP, and cGMP increased in patients with reduced systolic function and were the highest in dHF patients.
Conversely, corin levels were low in patients with reduced EF with or without dHF.
This pattern suggests possible enzymatic downregulation of natriuretic peptide activity in patients with reduced EF, which may have diagnostic and prognostic implications.
American Psychological Association (APA)
Zaidi, Syed S.& Ward, Ryan D.& Ramanathan, Kodangudi& Yu, Xinhua& Gladysheva, Inna P.& Reed, Guy L.. 2018. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128366
Modern Language Association (MLA)
Zaidi, Syed S.…[et al.]. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128366
American Medical Association (AMA)
Zaidi, Syed S.& Ward, Ryan D.& Ramanathan, Kodangudi& Yu, Xinhua& Gladysheva, Inna P.& Reed, Guy L.. Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128366