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MicroRNA Expression Profiling in Psoriatic Arthritis
المؤلفون المشاركون
Lunardi, C.
Antonio, Puccetti
Giuseppe, Argentino
Patuzzo, Giuseppe
Pelosi, Andrea
Fiore, Piera Filomena
Moretta, Francesca
Dolcino, Marzia
Tinazzi, E.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by bone erosions and new bone formation.
MicroRNAs (miRNAs) are key regulators of the immune responses.
Differential expression of miRNAs has been reported in several inflammatory autoimmune diseases; however, their role in PsA is not fully elucidated.
We aimed to identify miRNA expression signatures associated with PsA and to investigate their potential implication in the disease pathogenesis.
Methods.
miRNA microarray was performed in blood cells of PsA patients and healthy controls.
miRNA pathway analyses were performed and the global miRNA profiling was combined with transcriptome data in PsA.
Deregulation of selected miRNAs was validated by real-time PCR.
Results.
We identified specific miRNA signatures associated with PsA patients with active disease.
These miRNAs target pathways relevant in PsA, such as TNF, MAPK, and WNT signaling cascades.
Network analysis revealed several miRNAs regulating highly connected genes within the PsA transcriptome.
miR-126-3p was the most downregulated miRNA in active patients.
Noteworthy, miR-126 overexpression induced a decreased expression of genes implicated in PsA.
Conclusions.
This study sheds light on some epigenetic aspects of PsA identifying specific miRNAs, which may represent promising candidates as biomarkers and/or for the design of novel therapeutic strategies in PsA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pelosi, Andrea& Lunardi, C.& Fiore, Piera Filomena& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. 2018. MicroRNA Expression Profiling in Psoriatic Arthritis. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128389
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pelosi, Andrea…[et al.]. MicroRNA Expression Profiling in Psoriatic Arthritis. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1128389
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pelosi, Andrea& Lunardi, C.& Fiore, Piera Filomena& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. MicroRNA Expression Profiling in Psoriatic Arthritis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128389
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128389
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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