MicroRNA Expression Profiling in Psoriatic Arthritis
Joint Authors
Lunardi, C.
Antonio, Puccetti
Giuseppe, Argentino
Patuzzo, Giuseppe
Pelosi, Andrea
Fiore, Piera Filomena
Moretta, Francesca
Dolcino, Marzia
Tinazzi, E.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by bone erosions and new bone formation.
MicroRNAs (miRNAs) are key regulators of the immune responses.
Differential expression of miRNAs has been reported in several inflammatory autoimmune diseases; however, their role in PsA is not fully elucidated.
We aimed to identify miRNA expression signatures associated with PsA and to investigate their potential implication in the disease pathogenesis.
Methods.
miRNA microarray was performed in blood cells of PsA patients and healthy controls.
miRNA pathway analyses were performed and the global miRNA profiling was combined with transcriptome data in PsA.
Deregulation of selected miRNAs was validated by real-time PCR.
Results.
We identified specific miRNA signatures associated with PsA patients with active disease.
These miRNAs target pathways relevant in PsA, such as TNF, MAPK, and WNT signaling cascades.
Network analysis revealed several miRNAs regulating highly connected genes within the PsA transcriptome.
miR-126-3p was the most downregulated miRNA in active patients.
Noteworthy, miR-126 overexpression induced a decreased expression of genes implicated in PsA.
Conclusions.
This study sheds light on some epigenetic aspects of PsA identifying specific miRNAs, which may represent promising candidates as biomarkers and/or for the design of novel therapeutic strategies in PsA.
American Psychological Association (APA)
Pelosi, Andrea& Lunardi, C.& Fiore, Piera Filomena& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. 2018. MicroRNA Expression Profiling in Psoriatic Arthritis. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128389
Modern Language Association (MLA)
Pelosi, Andrea…[et al.]. MicroRNA Expression Profiling in Psoriatic Arthritis. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1128389
American Medical Association (AMA)
Pelosi, Andrea& Lunardi, C.& Fiore, Piera Filomena& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. MicroRNA Expression Profiling in Psoriatic Arthritis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128389